Category: Science

Supplementary Instruction for Research Trainees using a Peer Assisted Study Session Approach

Background: Although peer support is common in research training, supplementary instruction using Peer Assisted Study Sessions (PASS) is an approach yet to be applied to research training. Objectives: …

Bardoxolone Methyl Prevents Fat Deposition and Inflammation in Brown Adipose Tissue and Enhances Sympathetic Activity in Mice Fed a High-Fat Diet

Obesity results in changes in brown adipose tissue (BAT) morphology, leading to fat deposition, inflammation, and alterations in sympathetic nerve activity. Bardoxolone methyl (BARD) has been extensively studied…

Bardoxolone methyl prevents insulin resistance and the development of hepatic steatosis in mice fed a high-fat diet

High-fat (HF) diet-induced obesity is a major risk factor for the development of insulin resistance and hepatic steatosis. We examined the hypothesis that bardoxolone methyl (BM) would prevent…

Palmitic acid induces central leptin resistance and impairs hepatic glucose and lipid metabolism in male mice

The consumption of diets rich in saturated fat largely contributes to the development of obesity in modern societies. A diet high in saturated fats can induce inflammation and…

Bardoxolone methyl prevents fat deposition and inflammation in the visceral fat of mice fed a high-fat diet

Key features of diet-induced obesity are visceral fat deposition, macrophage infiltration and inflammation that can lead to metabolic disorders. This study examined the effects of bardoxolone methyl (BARD)…

Bardoxolone methyl prevents high-fat diet-induced alterations in prefrontal cortex signalling molecules involved in recognition memory

High fat (HF) diets are known to induce changes in synaptic plasticity in the forebrain leading to learning and memory impairments. Previous studies of oleanolic acid derivatives have…

Is B-type Natriuretic Peptide a Risk Factor for Heart Failure in Patients Treated With Bardoxolone Methyl?

Camer D, Huang XF: Is B-type Natriuretic Peptide a Risk Factor for Heart Failure in Patients Treated With Bardoxolone Methyl? J Cardiac Fail 2015, 21: 258-259. (Letter to…

The Endothelin Pathway: A Protective or Detrimental Target of Bardoxolone Methyl on Cardiac Function in Patients with Advanced Chronic Kidney Disease?

Bardoxolone methyl has been reported to cause detrimental cardiovascular events in the terminated BEACON Phase III human clinical trial via modulation of the renal endothelin pathway. However, the…

Oleanolic acid co-administration alleviates ethanol-induced hepatic injury via Nrf-2 and ethanol-metabolizing modulation (sic) in rats

Camer D, Huang XF: Comment on: Oleanolic acid co-administration alleviates ethanol-induced hepatic injury via Nrf-2 and ethanol-metabolizing modulation (sic) in rats. Chem Biol Interact 2014, 223C:116. (Letter to…

The molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complications

Recent research has uncovered the molecular mechanisms responsible for the therapeutic properties of oleanolic acid (OA), its isomer ursolic acid (UA), and derivatives. In particular, recent reports have…